The veterinary drug nosiheptide was first discovered by French scientists in Streptom-yces actlloslZS 40037 fermentation broth in 1961. It was then trial-produced by Rhone-Poulenc and fed in several countries and regions. The study of naxipeptide in China Beginning in 1989, in 1992, it was included in the “Eighth Five-Year Plan” project of the Ministry of Agriculture; in 1998, it was approved as China’s three new types of veterinary drugs; in 2002, it was industrialized by Hangzhou Huineng Biotechnology Co., Ltd. and Fudan University School of Pharmacy. After the study, it was put on the market in large quantities in 2003.
English name: Nosiheptide
Chinese synonyms: nosiheptide; nosiheptide; nopeptidin; nosiheptide 90%; nosiheptide 1% premixed powder
Molecular formula: C51H43N13O12S6
Molecular weight: 1222.38
MOL File: 56377-79-8.mol
Melting point (°C): 310～320
Specific optical rotation: : D20 +38° (c = 1 in pyridine)
Properties: light yellow to light yellow brown crystalline powder
Solution: almost insoluble in water, soluble in chloroform, soluble in cyclohexane, slightly soluble in ethanol.
The use of Nosiheptide:
It can prevent protein synthesis in microbial cells and feed pigs, which can promote weight gain and increase feed conversion rate. The European Economic Community stipulates that for broilers, 1 to 10 g per ton of feed is added; for pigs within 6 months of age, 2 to 20 g per ton of feed is added. The amount of additives specified in the Japanese Feed Safety Law is 2.5 to 10 g per ton of feed and 2.5 to 20 g of pig feed.
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